Genetic and chemical control of tuberculostearic acid production in Mycobacterium avium subspecies paratuberculosis
JP Bannantine, SC Duffy… - Microbiology …, 2024 - Am Soc Microbiol
… variability in fatty acid profiles produced by these mycobacteria in … This fatty acid is present
in the fast-growing species … is that co-enzyme A pools are being used up as pivalic acid-CoA, …
in the fast-growing species … is that co-enzyme A pools are being used up as pivalic acid-CoA, …
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection
… Mycobacterium tuberculosis depends on host fatty acids as a … As expected, based on the
affinity profile and function of Pox3… in the construct the constitutive promoter hsp60 to avoid …
affinity profile and function of Pox3… in the construct the constitutive promoter hsp60 to avoid …
Characterization of key enzymes involved in triacylglycerol biosynthesis in mycobacteria
A Crotta Asis, F Savoretti, M Cabruja, H Gramajo… - Scientific Reports, 2021 - nature.com
… increased levels of odd chain fatty acids esterified into TAGs, … We analyzed the lipid profile
of these recombinant strains by … widely described in many mycobacteria species including M. …
of these recombinant strains by … widely described in many mycobacteria species including M. …
Inhibition of fatty acid oxidation promotes macrophage control of mycobacterium tuberculosis
P Chandra, L He, M Zimmerman, G Yang, S Köster… - MBio, 2020 - Am Soc Microbiol
… This strain constitutively expresses mCherry and expresses green fluorescent protein (GFP) …
targets an enzyme in the mitochondria (32), a major site of reactive oxygen species (ROS) …
targets an enzyme in the mitochondria (32), a major site of reactive oxygen species (ROS) …
Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence
W Dong, X Nie, H Zhu, Q Liu, K Shi… - Proceedings of the …, 2021 - National Acad Sciences
… The fadA2 and fadE23-fadE24 encode enzymes of fatty acid β-… ∆fdmR mutant exhibited
constitutively high expression of the … We speculate that the resulting changes in acyl-CoA profiles …
constitutively high expression of the … We speculate that the resulting changes in acyl-CoA profiles …
Lineage-specific differences in lipid metabolism and its impact on clinical strains of Mycobacterium tuberculosis
K Moopanar, NE Mvubu - Microbial pathogenesis, 2020 - Elsevier
… These are effectively synthesized using a complex fatty acid … [86] reported diverse lipid profiles
and palmitic acid uptake … nitrous oxide treatment, are constitutively overexpressed in East-…
and palmitic acid uptake … nitrous oxide treatment, are constitutively overexpressed in East-…
Tuberculostearic acid controls mycobacterial membrane compartmentalization
M Prithviraj, T Kado, JA Mayfield, DC Young… - Mbio, 2023 - Am Soc Microbiol
… the enzymes that mediate the biosynthesis of this fatty acid … Fluorescence intensity profiles
along the long axis of the cells … While these studies used iso and anteiso fatty acids in other …
along the long axis of the cells … While these studies used iso and anteiso fatty acids in other …
Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity
H Yang, F Wang, X Guo, F Liu, Z Liu, X Wu, M Zhao… - Cell discovery, 2021 - nature.com
… The expression profiles of mycobacterial and host genes … Compared with the case for the
constitutively active Rpl30 locus… , a key enzyme for the fourth step of reaction in the fatty acid β-…
constitutively active Rpl30 locus… , a key enzyme for the fourth step of reaction in the fatty acid β-…
Engineering diverse fatty acid compositions of phospholipids in Escherichia coli
W Bai, WE Anthony, CJ Hartline, S Wang, B Wang… - Metabolic …, 2022 - Elsevier
… In Gram-negative bacteria, the fatty acid (FA) profile of lipid membranes … The Mycobacterium
smegmatis enzymes (strain IBFA-5) … Constitutively expressed sgRNAs were introduced on a …
smegmatis enzymes (strain IBFA-5) … Constitutively expressed sgRNAs were introduced on a …
Microbial fatty acid transport proteins and their biotechnological potential
JM Salvador Lopez… - Biotechnology and …, 2021 - Wiley Online Library
… be constitutively expressed and able to import fatty acids as free … Mycobacterium tuberculosis
which may be able to import free … This enzyme was expressed to generate free fatty acids …
which may be able to import free … This enzyme was expressed to generate free fatty acids …